Number of sites that are occupied by calcium on a protein Q B,ĭialysate flow rate at dialysate inlet Q E,įlow of citrate-containing fluid Q PRE,įlow rate of replacement fluid downstream of dialyzer Q pwinlet, Plasma clearance of citrate in the body K tot, Plasma clearance of citrate on the filter/dialyzer K patient, Plasma clearance of calcium in the dialyzer K CaB,Įquilibrium association constant for calcium bicarbonate K CaCit,Įquilibrium association constant for calcium citrate K CaCit2,Įquilibrium association constant for calcium dicitrate K CaCO3,Įquilibrium association constant for calcium carbonate K CaCO3,Įquilibrium association constant for calcium carbonate K CaP,Įquilibrium association constant for calcium phosphate K dialyzer, Systemic ionized calcium reference level in blood J citload, Systemic ionized calcium reference level iCit, Plasma water fraction post-dialyzer G met, Total citrate in the plasma water post-dialyzer Cit tot,įraction of patient plasma total calcium made availabe in plasma water for transfer through dialyzer membrane after citrate infusion F DIL,ĭilution ratio from plasma water reaching dialyzer fpw, Total calcium in the plasma water post-dialyzer Ca tot, No commercial affiliation will alter our adherence to PLOS ONE policies on sharing data and materials. Baxter Healthcare Corporation provided salaries for the authors IF, AN, AW, but did not have any additional role in the study design, data collection and analysis or decision to publish. Bodelsson and Broman are employed by Skåne University Hospital. Baxter Healthcare Corporation provided salaries for the authors IF, AN, AW, but did not have any additional role in the study design, data collection and analysis or decision to publish.Ĭompeting interests: Forsal, Nilsson and Wieslander are employed by Baxter Healthcare Corporation. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.ĭata Availability: All relevant data is in the paper.įunding: Forsal, Nilsson and Wieslander are employed by Baxter Healthcare Corporation. Received: Accepted: FebruPublished: February 25, 2021Ĭopyright: © 2021 Forsal et al. PLoS ONE 16(2):Įditor: Vince Grolmusz, Mathematical Institute, HUNGARY This study supports the use of the i-STAT PCA for the evaluation of these analytes, with the exception of K, in the Asian elephant.Citation: Forsal I, Nilsson A, Bodelsson M, Wieslander A, Broman M (2021) Mathematical modelling of post-filter ionized calcium during citrate anticoagulated continuous renal replacement therapy. Within the reference range for iCa 2, the iCa 2 values obtained by the i-STAT PCA and Radiometer ABL 800 Flex were close in value, however in light of the constant and proportionate biases detected, overestimation at higher values and underestimation at lower values of iCa 2 by the i-STAT PCA would be of potential concern. Despite bias, mean differences assessed via Bland-Altman plots were clinically acceptable for all analytes excluding K. Comparison of the results from the two analyzers at 4 hr postsampling found very strong or strong correlation in all values except K, with statistically significant bias in all values except glucose and PCO 2. Statistical analysis using correlation coefficients, Passing-Bablok regression analysis, and Bland-Altman plots found good agreement between results from samples run immediately after phlebotomy and 4 hr postsampling on the i-STAT PCA with the exception of K, which is known to change with sample storage. Analytes evaluated were hydrogen ion concentration (pH), glucose, potassium (K ), sodium (Na ), bicarbonate (HCO 3 −), total carbon dioxide (TCO 2), partial pressure of carbon dioxide (PCO 2), and ionized calcium (iCa 2 ). In addition, the effect of sample storage was evaluated on the i-STAT PCA. In this study, the i-STAT PCA was compared with the Radiometer ABL 800 Flex benchtop analyzer using 24 heparinized whole blood samples obtained from healthy E. This analyzer is commonly used in nondomestic animals however, validation of this method in comparison with traditional benchtop methods should be performed for each species.
Ionized calcium istat portable#
Thei-STAT® portable clinical analyzer (PCA) provides patient-side results for hematologic, biochemical, and blood gas values when immediate results are desired.
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